Endocrine Abstracts

Objectives: Secretion of GH, a pituitary and anabolic hormone that reduces visceral fat, is diminished in obese or elderly subjects. The reduced GH may induce visceral fat accumulation and subsequently accelerate metabolic syndrome in these population. In the present study, we sought the effect of chronic GH supplement on visceral fat and glucose metabolism in diet-induced obese (DIO) mice.Methods and results: Male obese mice (C57BL/6, 12 weeks old) unde...

Objective: The aim of this study was to investigate whether SUR2A (sulfonylurea receptor type 2A, ABCC9) MEF2a (myocyte enhancer factor-2a) and HIF1a (Hypoxia-inducible factor-1) can influence glucose uptake in oxidative muscle soleus by regulating GLUT4 expression.Methods: Insulin resistance was induced in male Wistar rats by inducing obesity with monosodium glutamate (MSG). At the age 3 months, half control and MSG-treated animals started receiving 0.1...

Background: Reduced GLUT4 expression in insulin-sensitive tissues, insulin resistance, inflammation, nonalcoholic steatohepatitis (NASH) and hypertension are pathophysiologic changes expected in metabolic syndrome animal models.Aims: To fully characterize the development and maintenance of metabolic syndrome features over time (GLUT4 in insulin-sensitive tissues, insulin resistance, inflammation, blood pressure and liver changes) in spontaneously hyperte...

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

Introduction: Considering the high capacity of water transport of Na+/glucose cotransporter SGLT1, the aim of this study was to investigate the potential role the SGLT1 in luminal membrane of ductal cells of salivary glands upon the non-stimulated salivary secretion of diabetic rats. The present study also investigates the presence of glucose transporter GLUT1 in salivary glands of rats.Methods: Non-stimulated salivary secretion and SGLT1/GLUT1 protein (...